Publications by authors named "B Oostra"
Background: Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having an association with both lean mass and fat mass.
View Article and Find Full Text PDFIn the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper.
View Article and Find Full Text PDFArticle Synopsis
- High blood pressure is a significant risk factor for cardiovascular disease and is influenced by genetics, but it can be modified through lifestyle changes.
- This research is the largest genetic study on blood pressure, involving over 1 million individuals of European descent, identifying 535 new genetic loci related to blood pressure traits like systolic and diastolic pressure.
- The study reveals new biological pathways for regulating blood pressure, which could lead to better prevention strategies for cardiovascular disease in the future.
Article Synopsis
- The study examined the genetics behind electrocardiographic measures of left ventricular hypertrophy (LVH) to identify rare genetic variants associated with increased cardiovascular risk.
- Researchers analyzed data from a Dutch family study and linked genetic variations with specific heart measurement traits, finding notable scores on chromosome 15 and identifying variants through exome sequencing.
- A rare variant in the MAPK3K11 gene on chromosome 11 was highlighted as a potential contributor to cardiovascular risk, indicating its role in heart cell death related to LVH conditions.
Intellectual disability (ID) comprises a large group of heterogeneous disorders, often without a known molecular cause. X-linked ID accounts for 5-10% of male ID cases. We investigated a large, three-generation family with mild ID and behavior problems in five males and one female, with a segregation suggestive for X-linked inheritance.
View Article and Find Full Text PDF