Publications by authors named "B Offersen"

Background: Internal mammary node irradiation (IMNI) improves overall survival (OS) in node-positive breast cancer patients. However, the effect is not documented in breast cancer patients treated with newer systemic therapies and 3D-based radiotherapy (RT). Therefore, the Danish Breast Cancer Group (DBCG) IMN2 study aimed to investigate the effect of IMNI in node-positive breast cancer patients treated with newer systemic therapies and 3D-based RT.

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Background And Purpose: Radiotherapy improves outcomes for breast cancer. However, prior studies have correlated the risk of coronary artery disease (CAD) to the mean heart dose (MHD), mean dose to the left anterior descending artery (LAD_mean) and the left ventricle V5Gy (LV5). Other studies showed an increased risk of CAD for patients with pronounced coronary artery calcification (CAC) at the time of radiotherapy.

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Article Synopsis
  • - This study examined how different interpretations of guidelines for outlining left-sided internal mammary lymph nodes (IMN) affect radiation exposure to nearby organs in breast cancer patients.
  • - Using a cohort of 95 patients, it compared the NKI's interpretation with a deep learning model based on Danish guidelines, finding significant geometric and dosimetric differences, especially regarding heart dose.
  • - The results indicated that variability in guideline interpretations can lead to higher heart radiation doses, highlighting the importance of establishing a uniform consensus in treatment practices to improve patient outcomes.
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Article Synopsis
  • * The study included nearly 7,000 patients, revealing that the median heart volume increased over time, and the median mean heart dose (MHD) remained low, indicating effective radiation management.
  • * Findings suggest that, despite an increase in heart volume, the average heart dose during treatment was minimal, demonstrating the feasibility of large-scale audits with automated tools for better patient care.
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Collecting large amounts of radiotherapy (RT) data from clinical systems is known to be a challenging task. Still, data collections outside the original RT systems are needed to follow-up on the quality of cancer care and to improve RT. This paper aims to describe how RT data is collected nationally in Denmark and Sweden for this purpose and gives an overview of the stored information in both countries' national data sources.

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