Potential locations for non-invasive brain stimulation in treating ADHD: Results from a cross-dataset validation of functional connectivity analysis.

Noninvasive brain stimulation (NIBS) has emerged as a promising therapeutic approach for attention-deficit/hyperactivity disorder (ADHD), yet the inaccurate selection of stimulation sites may constrain its efficacy. This study aimed to identify novel NIBS targets for ADHD by integrating meta-analytic findings with cross-dataset validation of functional connectivity patterns. A meta-analysis including 124 functional magnetic resonance imaging (fMRI) studies was first conducted to delineate critical brain regions associated with ADHD, which were defined as regions of interest (ROIs).

Post-translational modifications orchestrate the intrinsic signaling bias of GPR52.

Despite recent advances in G-protein-coupled receptor (GPCR) biology, the regulation of GPCR activation, signaling and function by post-translational modifications (PTMs) remains largely unexplored. In this study of GPR52, an orphan GPCR with exceedingly high constitutive G-protein activity that is emerging as a neurotherapeutic target, we discovered its disproportionately low arrestin recruitment activity. After profiling the N-glycosylation and phosphorylation patterns, we found that these two types of PTMs differentially shape the intrinsic signaling bias of GPR52.

Effect of polysaccharides and saponins from Polygonatum kingianum against uranium-induced renal injury in rats.

Uranium poisoning is increasingly recognized as a public health issue. Polygonatum kingianum (PK) is valued for its therapeutic properties and food applications. Original research showed PK aqueous extract (PKAE) and polysaccharides (PKP) could alleviate uranium-induced cytotoxicity in vitro.

Chlorogenic acid mitigates avian pathogenic Escherichia coli-induced intestinal barrier damage in broiler chickens via anti-inflammatory and antioxidant effects: CHLOROGENIC ACID AND BROILER CHICKENS.

This study was conducted to investigate the protective effects of chlorogenic acid (CGA) on intestinal health in broilers challenged with avian pathogenic Escherichia coli (APEC). One hundred and eighty one-day-old male broiler chicks were divided into three groups with six replicates of ten chicks each for a 21-day trial. The birds in the control and APEC groups were fed a basal diet, while birds in the CGA-treated group received a basal diet supplemented with 1000 mg/kg of CGA.