Publications by authors named "B O Sanches"

Cancer and its diverse variations pose one of the most significant threats to human health and well-being. One of the most aggressive forms is blood cancer, originating from bone marrow cells and disrupting the production of normal blood cells. The incidence of blood cancer is steadily increasing, driven by both genetic and environmental factors.

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Telocytes are CD34 interstitial cells that have long cytoplasmic projections (called telopodes), and have been detected in several organs, including those of the male reproductive system. In this brief review we evaluate the role of telocytes in tissue organization of the different organs of the male reproductive system in which these cells were studied. In general terms, telocytes act in the tissue organization through networks of telopodes that separate the epithelia from the stroma, as well as dividing the stroma into different compartments.

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Malignant lymphoma is an unusual form of gallbladder neoplasm. Almost all these tumors are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas. Herein, we present a literature review of gallbladder Burkitt's lymphoma (BL) cases that includes also an unpublished case in an HIV-infected child, observed by our center.

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Introduction: The objective of the current study was to determine the survival probabilities of children and adolescents with acute lymphocytic leukemia treated with adapted Berlin-Frankfurt-Münster (BFM) protocols and compare our results with the original BFM reports.

Methods: This retrospective study included 695 patients up to 19 years old treated with adapted BFM protocols between 1997 and 2018 in four hospitals in Rio de Janeiro. The 1997-2007 and 2008-2018 cohorts were analyzed separately.

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Article Synopsis
  • The renin-angiotensin system (RAS) is essential for cardiovascular health, with key peptides like angiotensin-II and angiotensin-(1-7) playing major roles.
  • Recent research shows that alamandine (ALA) interacts with heart cells (cardiomyocytes) and influences their contraction based on the time of day, showing positive effects during the light phase and negative during the dark phase.
  • These results indicate that the effects of ALA through the MrgD receptor vary with circadian rhythms, suggesting new avenues for timing-based therapies to treat heart conditions linked to disrupted biological clocks.
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