Targeting SETDB1 in cancer and immune regulation: Potential therapeutic strategies in cancer.

SET domain bifurcated histone lysine methyltransferase 1 (SETDB1/ESET), a pivotal H3K9 methyltransferase, has been extensively studied since its discovery over two decades ago. SETDB1 plays critical roles in immune regulation, including B cell maturation, T-cell activity modulation, and endogenous retrovirus (ERV) silencing. While essential for normal immune cell function, SETDB1 overexpression in cancer cells disrupts immune responses by suppressing tumor immunogenicity and facilitating immune evasion.

Regulation of important natural products biosynthesis by WRKY transcription factors in plants.

Background: Plants produce abundant natural products, among which are species-specific and diversified secondary metabolites that are essential for growth and development, as well as adaptation to adversity and ecology. Moreover, these secondary metabolites are extensively utilized in pharmaceuticals, fragrances, industrial materials, and more. WRKY transcription factors (TFs), as a family of TFs unique to plants, have significant functions in many plant life activities.

Oxidative Polymerization in Water Treatment: Chemical Fundamentals and Future Perspectives.

For several decades, the methodology of complete destruction of organic pollutants via oxidation, i.e., mineralization, has been rooted in real water treatment applications.

A narrow band blue phosphor NaBaAlBOCl:Eu for white light emitting diodes.

Exploring new photoexcited phosphors has attracted attention for improving the performance of white LEDs. Here, an NaBaAlBOCl:Eu phosphor with high color purity (94.11%) has been synthesized.

Efficacy of the 28S rDNA barcode in differentiating Caribbean octocorals.

The ecological landscape of Caribbean reefs is rapidly changing as octocorals fill the void left by declining scleractinian populations. Effective molecular barcodes are necessary to accurately identify these octocorals and monitor this shifting ecosystem. We tested the efficacy of the as a barcode compared to the most commonly used barcode on a collection of octocorals from across the Caribbean.