The role of cisplatin in modulating the tumor immune microenvironment and its combination therapy strategies: a new approach to enhance anti-tumor efficacy.

Cisplatin is a platinum-based drug that is frequently used to treat multiple tumors. The anti-tumor effect of cisplatin is closely related to the tumor immune microenvironment (TIME), which includes several immune cell types, such as the tumor-associated macrophages (TAMs), cytotoxic T-lymphocytes (CTLs), dendritic cells (DCs), myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), and natural killer (NK) cells. The interaction between these immune cells can promote tumor survival and chemoresistance, and decrease the efficacy of cisplatin monotherapy.

Integration of Flexible Thermoelectric Energy Harvesting System for Self-Powered Sensor Applications.

Flexible thermoelectric generators (FTEGs) can continuously harvest energy from the environment or the human body to supply wearable electronic devices, which should be a clean energy solution and provide an opportunity to satisfy the increasing power consumption of multimodal sensing and data transmission in wearable electronic devices. Here, the 64-pair FTEG was fabricated by introducing the plated through-hole and heterotypic electrode structures to optimize the thermal transport, showing the largely improved output power of 4.1 mW and record-high power density of 312 μW cm at a given ambient temperature of 15 °C inside a measurement equipment.

Association between underlying conditions, multimorbidity, and COVID-19 vaccination status of adults aged ≥80 years old in Beijing, China.

Background: Promoting coronavirus disease 2019 (COVID-19) vaccination is crucial among older adults, particularly those geriatric. This study aimed to analyze the association between chronic conditions, multimorbidity, and vaccination status in adults aged ≥80 years old to provide recommendations for vaccine-preventable diseases.

Methods: A cross-sectional study was conducted in Beijing from April 5, 2023, to May 5, 2023, including participants aged ≥80 years old who did not receive the booster COVID-19 vaccination.

Local corner smoothing based on deep learning for CNC machine tools.

Most of toolpaths for machining is composed of series of short linear segments (G01 command), which limits the feedrate and machining quality. To generate a smooth machining path, a new optimization strategy is proposed to optimize the toolpath at the curvature level. First, the three essential components of optimization are introduced, and the local corner smoothness is converted into an optimization problem.

Serum exosome-derived ALDH1A1 can greatly predict the prognosis of patients with hepatitis E virus-related acute liver failure.

Background: Despite the insights into the role of aldehyde dehydrogenase 1 family member A1 (ALDH1A1) in various liver diseases, the expression and its prognostic significance in patients with hepatitis E virus-related acute liver failure (HEV-ALF) remain unclear. This study delved into the assessment of serum exosome-derived ALDH1A1 expression and its prognostic implications for HEV-ALF patients.

Methods: Between January 2018 and December 2023, a total of 226 individuals with acute hepatitis E (AHE) and 210 patients with HEV-ALF were recruited from member units of Chinese Consortium for the Study of Hepatitis E.