Generation of binder-format-payload conjugate-matrices by antibody chain-exchange.

The generation of antibody-drug conjugates with optimal functionality depends on many parameters. These include binder epitope, antibody format, linker composition, conjugation site(s), drug-to-antibody ratio, and conjugation method. The production of matrices that cover all possible parameters is a major challenge in identifying optimal antibody-drug conjugates.

Redox-Active Carboranyl Diphosphine as an Electron and Proton Transfer Agent.

In this work, we report the first example of the PCET reactivity for a boron cluster compound, the zwitterionic -carboranyl diphosphonium derivative 7-P(H)Bu-10-P(H)Pr--CBH. This main-group reagent efficiently transfers two electrons and two protons to quinones to yield hydroquinones and regenerate a neutral -carboranyl diphosphine, 1-PBu-2-PPr--CBH. As we have previously reported the conversion of this -carboranyl diphosphine into the zwitterionic derivative upon reaction with main group hydrides, the transformation reported herein represents a complete synthetic cycle for the metal-free reduction of quinones, with the redox-active carboranyl diphosphine scaffold acting as a mediator.

Development of a Medication-Use Evaluation Template for Andexanet Alfa in the Reversal of Anticoagulation With Factor Xa Inhibitors.

Medication-use evaluations are meant to ensure that medication-use processes are consistent with prevailing standards of care, assure optimal use of therapy, and reduce the risk of medication-related problems. Reversal agents for direct oral anticoagulants are a worthy focus for medication-use evaluations for reasons of efficacy, safety, and cost. A multidisciplinary team of experts developed 2 medication-use evaluation templates illustrating the application of professional society guidelines to the appropriate use of andexanet alfa.

Redox-active carborane clusters in bond activation chemistry and ligand design.

Icosahedral -dodecaboranes have the ability to accept two electrons, opening into a dianionic -cluster. This transformation can be utilized to store electrons, drive bond activation, or alter coordination to metal cations. In this feature article, we present cases for each of these applications, wherein the redox activity of carborane facilitates the generation of unique products.