Publications by authors named "B Neuman"
The COVID-19 pandemic has profoundly impacted global economies and healthcare systems, revealing critical vulnerabilities in both. In response, our study introduces a groundbreaking method for the detection of SARS-CoV-2 cDNA, leveraging Luminescence resonance energy transfer (LRET) between upconversion nanoparticles (UCNPs) and gold nanoparticles (AuNPs) to achieve an unprecedented detection limit of 242 femtomolar (fM). This innovative sensing platform utilizes UCNPs conjugated with one primer and AuNPs with another, targeting the 5' and 3' ends of the SARS-CoV-2 cDNA, respectively, enabling precise differentiation of mismatched DNA sequences and significantly enhancing detection specificity.
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- Tranexamic acid (TXA) is used in adult spinal deformity surgery to reduce blood loss, but there's no agreed-upon dosing method.
- A study analyzed data from 265 complex ASD patients, categorizing them into low, medium, and high TXA dose groups and measuring blood loss, complications, and RBC transfusions.
- Findings revealed that lower TXA doses resulted in significantly higher blood loss and increased RBC transfusions compared to high doses, suggesting that higher TXA dosing may be more effective in minimizing blood loss during surgery.
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- The text reviews the increasing application of artificial intelligence (AI) in spine surgery, highlighting its roles in the preoperative, intraoperative, and postoperative stages.
- AI contributes to image analysis, patient diagnosis, and decision-making before surgery, aids navigation during surgery, and helps predict outcomes after surgery.
- The review also discusses ethical concerns regarding AI's use in healthcare, suggesting that making industry data more transparent could improve trust and patient care.
Science is humanity's best insurance against threats from nature, but it is a fragile enterprise that must be nourished and protected. The preponderance of scientific evidence indicates a natural origin for SARS-CoV-2. Yet, the theory that SARS-CoV-2 was engineered in and escaped from a lab dominates media attention, even in the absence of strong evidence.
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- This study investigates how different methods of assessing depression affect surgical outcomes in patients preparing for lumbar spine surgery, focusing on ecological momentary assessments (EMAs) compared to traditional methods like self-reported questionnaires (PHQ-9) and chart-based diagnoses.
- The research involved 122 adult patients who recorded their depressive symptoms multiple times daily for three weeks before surgery, with results showing only weak correlations between EMA scores and past depression diagnoses, while EMA scores demonstrated stronger links to surgical outcomes after six months.
- Findings revealed that patients awaiting spine surgery reported similar non-somatic symptoms of depression to the general population but had significantly more somatic symptoms; EMA assessments proved to be a more reliable indicator of