Validation of the predictive value of BDNF -87 methylation for antidepressant treatment success in severely depressed patients-a randomized rater-blinded trial.

Background: Brain-derived neurotrophic factor (BDNF) is essential for antidepressant treatment of major depressive disorder (MDD). Our repeated studies suggest that DNA methylation of a specific CpG site in the promoter region of exon IV of the BDNF gene (CpG -87) might be predictive of the efficacy of monoaminergic antidepressants such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and others. This trial aims to evaluate whether knowing the biomarker is non-inferior to treatment-as-usual (TAU) regarding remission rates while exhibiting significantly fewer adverse events (AE).

Corrigendum: A revision of the trichostrongylid nematode Ransom, 1907, from deer game: recent integrative research confirms the existence of the ancient host-specific species (Rudolphi, 1809).

[This corrects the article DOI: 10.3389/fvets.2024.

A revision of the trichostrongylid nematode Ransom, 1907, from deer game: recent integrative research confirms the existence of the ancient host-specific species (Rudolphi, 1809).

The trichostrongylid roundworms of the genus , which are important in veterinary medicine, currently comprise 19 valid species that parasitize the small intestine of both free-living and domestic ruminants. Only four spp. have been reported in Europe, namely and .

Epibiontic life on intertidal Setaphyes kielensis and S. dentatus (Kinorhyncha, Pycnophyidae) from Sylt, North Sea, Germany, with a description of a new species of Trematosoma (Ciliophora, Acinetidae) and a redescription of Cothurnia buetschlii (Ciliophora, Vaginicolidae).

Specimens of two species of Kinorhyncha, Setaphyes dentatus and S. kielensis, were collected in 1988, 1998, and 2016 at two intertidal sites on the island of Sylt, North Sea, and investigated as preserved material by light microscopy and scanning electron microscopy for their epibionts. One species of Acinetidae (Suctoria), one species of Vaginicolidae (Peritrichia), and two species of bacteria were traced.

The role of research competence as an influencing factor for the careers of young academics. Findings and implications from studies on doctorates in medicine and life sciences in Germany.

Background: When viewed internationally, Germany boasts a high rate of doctoral candidates. Fields such as medicine and life sciences have a notably high proportion of doctoral students, a trend rooted in historical factors. Despite this, comprehensive empirical studies concerning the doctoral phase and early-career researchers, especially in relation to the rise of structured doctoral programmes, have only recently gained traction.