Publications by authors named "B Negron"
Article Synopsis
- Reliable impurity detection in biopharmaceuticals is key for ensuring product quality and safety; however, traditional methods face technical challenges in accurately identifying individual impurities.
- This study introduces a size-based electrophoresis method combined with mass spectrometry to effectively detect and identify impurities in antibody production from known degradation products.
- By simulating cell culture conditions and forced degradation, the researchers demonstrate that this combined approach improves the detection and identification of impurities, enhancing the development process for antibody therapeutics.*
Chronic and subacute subdural hematoma in the adult population. The Puerto Rico experience.
P R Health Sci J
September 1998
Objective: The purpose of this investigation was to study the epidemiology of chronic and subacute subdural hematoma in an adult population and associated factors such as treatment, recurrence, seizures, complications, and outcome.
Methods: We retrospectively reviewed 267 consecutive cases operated for a suspected diagnosis of chronic or subacute subdural hematoma during a six-year period.
Results: An incorrect diagnosis was done in 12 of the cases (4.
Cystic meningiomas are uncommon tumors that are easily confused with metastatic or glial tumors that have cystic components. We have retrospectively reviewed all of the meningiomas operated on at the University of Puerto Rico in a 5-year period (1989-1993) and found only five cystic meningiomas (4.3% of total meningiomas).
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