Background: Many states throughout the United States have introduced Quality Rating and Improvement Systems (QRIS) to address childhood obesity in preschool-age children, but few have examined the impact of these standards in Family Child Care Homes (FCCHs). In South Carolina, the ABC Grow Healthy Practices are specific QRIS items that include diet, physical activity and sleep practices.
Methods: The purposes of this cross-sectional study are to (1) describe physical activity levels, sleep duration and diet quality of children attending FCCHs in South Carolina and (2) compare physical activity levels, sleep duration and diet quality between children attending FCCHs that were enrolled versus not enrolled in the ABC programme.
Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation and its causality to cachexia by exploring skeletal muscle, whose atrophy strongly associates with poor outcomes. Using multiple mouse models and patient samples, we show that cachectic muscle is marked by enhanced innate immunity.
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