Publications by authors named "B Nedoszytko"
(γδ) T cells are a heterogeneous population of cells that play roles in inflammation, host tissue repair, clearance of viral and bacterial pathogens, regulation of immune processes, and tumor surveillance. Recent research suggests that these are the main skin cells that produce interleukin-17 (I-17). Furthermore, γδ T cells exhibit memory-cell-like characteristics that mediate repeated episodes of psoriatic inflammation.
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- Hypersensitivity reactions (HR) are common in mastocytosis, a condition analyzed using data from the European Competence Network on Mastocytosis (ECNM), involving 2485 adults.
- About 38.1% of patients reported HR, with Hymenoptera venoms being the primary trigger for cutaneous mastocytosis and indolent systemic mastocytosis, while drug reactions were more common in advanced systemic mastocytosis.
- Key risk factors for HR include lower tryptase levels, minimal mast cell infiltration in bone marrow, and a diagnosis of indolent systemic mastocytosis, with new reactions occurring in 4.8% of patients over four years.
Article Synopsis
- - Mastocytosis is a disease linked to mast cells that can vary in severity, with the presence of the KIT p. D816V mutation playing a key role in its development, alongside potentially significant epigenetic factors that influence gene expression.
- - The study aimed to investigate differences in DNA methylation profiles between patients with indolent systemic mastocytosis (ISM) and healthy individuals, analyzing blood samples to identify regions of differing methylation (DMRs) that could indicate disease progression and management strategies.
- - Through analysis using a MethylationEPIC BeadChip kit and statistical methods like Limma, researchers assessed co-methylated regions to establish potential epigenetic predictors that could aid in understanding and treating mast
Circadian genes are a set of genes that regulate the body's internal clock and influence various physiological processes, including sleep-wake cycles, metabolism and immune function. Skin cutaneous melanoma (SKCM) is a type of skin cancer that arises from the pigment-producing cells in the skin and is the most deadly form of skin cancer. This study has investigated the relevance of circadian gene expression and immune infiltrations in the outcomes of cutaneous melanoma patients.
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- - Skin mast cells act as protective cells that respond rapidly to maintain balance in the body, helping to fight infections and facilitate healing when tissue is damaged.
- - These cells communicate with various body systems, including immune, nervous, and blood systems, by releasing certain substances.
- - The article examines the role of mast cells in various conditions, including allergies and skin diseases, as well as their involvement in systemic diseases that have significant skin-related symptoms.