Publications by authors named "B Naudin"
The ability of A. baumannii to develop biofilms on a wide range of surfaces can be associated to its persistence in hospital settings and the emergence of recalcitrant and chronic infections. Few compounds are available to eradicate A.
View Article and Find Full Text PDFEpicocconone is a natural latent fluorophore that is widely used in biotechnology because of its large Stokes shift and lack of fluorescence in its unconjugated state. However, the low photostability and quantum yields of epicocconone have limited its wider use, and in the absence of a total synthesis, this limitation has been a long-standing problem. Here we report a general strategy for the synthesis of epicocconone analogues that relies on a 2-iodoxybenzoic acid-mediated dearomatization and on the replacement of the triene tail of the natural product by an aromatic ring.
View Article and Find Full Text PDFIn order to provide reliable information about responsiveness of biomarkers during environmental monitoring, there is a need to improve the understanding of inter-population differences. The present study focused on eight populations of zebra mussels and aimed to describe how variable are biomarkers in different sampling locations. Biomarkers were investigated and summarised through the Integrated Biomarker Response (IBR index).
View Article and Find Full Text PDFArticle Synopsis
- In prokaryotes, N-glycosylation of proteins plays a key role in cell recognition and can be targeted for infection control, yet understanding of these proteins in Pseudomonas is limited.
- A new method involving biotinylated lectins was used to identify surface glycoproteins, leading to the discovery of potential N-glycoproteins including the abundant flagellin FliC.
- Further analysis revealed three potential glycosylation sites on FliC, indicating that this protein may exist as a complex mixture with different glycoforms.
Objective: To assess the impact of an educational program on the quality of the end-of-life decision (EOLD).
Methods: Prospective study for 3 months in a surgical Intensive Care Unit (ICU) involving: staff training conferences and guidelines for documenting level-of-care staff conference; audit before and at 3 months; analysis of records for deceased patients. The main outcome measures the proportion of treatment-limitation in dying ICU patients; and the secondary outcomes the decision-making process and nurses' satisfaction.