Publications by authors named "B Nardo"
Cell Commun Signal
November 2024
Article Synopsis
- Endocrine therapy improves outcomes for ERα+ breast cancer, but resistance remains a key challenge, often linked to mutations like Y537S in the hormone-binding domain of ERα.
- Researchers conducted coculture experiments to study interactions between mutant breast cancer cells (MCF-7YS) and fibroblasts (both normal and cancer-associated) to see how these interactions influence cancer progression.
- The study found that the Y537S mutation led to changes in fibroblast behavior and protein expression, with increased YAP1 involvement, suggesting that mutant breast cancer cells can enhance their growth and invasion capabilities through interactions with the tumor microenvironment.
Updates Surg
September 2024
Article Synopsis
- - This national survey aimed to assess the use of liver hypertrophy techniques in Italy, focusing on trends and differences among various medical centers.
- - In December 2022, 46 centers completed a detailed online questionnaire, revealing that hypertrophy techniques were used in 6.2% of liver resections, with PVE and ALPPS being the most common techniques employed.
- - The findings indicated that while these techniques play a crucial role in increasing resectability, there is substantial inconsistency in how centers define the need for them and the protocols used for patient allocation.
Article Synopsis
- Anal fissure is a common condition involving a tear in the anal tissue, leading to pain and bleeding during bowel movements.
- Chronic anal fissures can severely affect a person's quality of life, requiring various treatment options.
- This article reviews the historical development of our understanding and treatment of anal fissures, marking significant milestones from ancient times to today.
Article Synopsis
- The REDISCOVER consensus conference focused on creating guidelines for the perioperative care of patients with borderline-resectable and locally advanced pancreatic ductal adenocarcinoma (PDAC).
- Using a structured methodology and expert consensus, the conference developed 34 recommendations on various aspects of surgical care, patient selection, and management of pancreatic cancer.
- Despite the low evidence quality for most recommendations, participants highlighted the importance of establishing an international registry to enhance understanding and care for this patient group.
