Publications by authors named "B Napoleon"
Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET), previously called ampullary gangliocytic paragangliomas, is a rare entity, with only few reported cases in the literature. This is a multicentric retrospective cohort study of patients treated with endoscopy or surgery for ampullary CoGNET. A literature review of ampullary CoGNET was also performed.
View Article and Find Full Text PDFObjective: Ampullary neoplastic lesions can be resected by endoscopic papillectomy (EP) or transduodenal surgical ampullectomy (TSA) while pancreaticoduodenectomy is reserved for more advanced lesions. We present the largest retrospective comparative study analysing EP and TSA.
Design: Of all patients in the database, lesions with prior interventions, benign histology advanced malignancy (T2 and more), patients with hereditary syndromes and those undergoing pancreatoduodenectomy were excluded.
Article Synopsis
- Stent misdeployment (SMD) is a significant challenge in EUS-guided choledochoduodenostomy (EUS-CDS) for treating malignant distal biliary obstruction, with the study aiming to define its rate and outcomes, and propose a classification system.
- In a review of data from two randomized controlled trials involving 152 patients, SMD was found in 7.2% of cases, with most types being misdeployments of the distal flange (type I) and a small number causing minor adverse events.
- The analysis revealed that a smaller extrahepatic bile duct diameter (≤ 15 mm) increases the likelihood of SMD or technical failures, but most misdeployments can be successfully managed
Article Synopsis
- The study utilized endoscopic ultrasound-guided fine needle aspiration biopsy to diagnose and analyze genetic material from primary pancreatic tumors in 397 patients with pancreatic adenocarcinoma.
- Key findings revealed significant differences in molecular profiles between metastatic and non-metastatic tumors, including varying mutation rates of KRAS and TP53.
- The researchers suggested that genomic and transcriptomic profiling could help predict survival outcomes for patients undergoing specific chemotherapy treatments, informing future therapeutic strategies.
Article Synopsis
- Management of ampullary tumors (AT), which include adenomas (AA) and carcinomas (AC), is tough because there's not a lot of solid research on it.
- The French medical community worked together to create guidelines based on recent studies and expert advice, which categorize recommendations by how strong the evidence is.
- Accurate diagnosis requires special tests, and every patient should have their case reviewed by a team of different doctors before deciding on treatment, with a recommended follow-up period of 5 years.