Listeners recognizing environmental sounds must contend with variations in level due to the source level and the environment. Nonetheless, variations in level disrupt short-term sound recognition [Susini, Houix, Seropian, and Lemaitre (2019). J.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) is a typically fatal malignancy exhibiting genetic heterogeneity and limited therapy responses. We demonstrate here that HCCs consistently repress urea cycle gene expression and thereby become auxotrophic for exogenous arginine. Surprisingly, arginine import is uniquely dependent on the cationic amino acid transporter SLC7A1, whose inhibition slows HCC cell growth in vitro and in vivo.
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