Publications by authors named "B Namjou-Khales"
Elevated cholesterol poses a significant cardiovascular risk, particularly in older women. The glucocorticoid receptor (GR), a crucial nuclear transcription factor that regulates the metabolism of virtually all major nutrients, harbors a still undefined role in cholesterol regulation. Here, we report that a coding single nucleotide polymorphism (SNP) in the gene encoding the GR, , associated with increased cholesterol levels in women according to UK Biobank and All Of Us datasets.
View Article and Find Full Text PDFObjective: High BMI is associated with many comorbidities and mortality. This study aimed to elucidate the overall clinical risk of obesity using a genome- and phenome-wide approach.
Methods: This study performed a phenome-wide association study of BMI using a clinical cohort of 736,726 adults.
Article Synopsis
- Immunoglobulin A (IgA) plays a crucial role in immune response to food and pathogens and is linked to various conditions like celiac disease and inflammatory bowel disease.
- A genome-wide association study examined blood IgA levels in over 41,000 people, identifying 20 key genetic loci that affect IgA levels, including novel genes.
- Findings suggest genetic factors influencing IgA can impact diseases such as IgA nephropathy and type 2 diabetes, with African ancestry showing higher IgA levels and more IgA-increasing genetic variants.
Background: Lp(a) (lipoprotein [a]) levels are higher in individuals of African ancestry (AA) than in individuals of European ancestry (EA). We examined associations of genetically predicted Lp(a) levels with (1) atherosclerotic cardiovascular disease subtypes: coronary heart disease, cerebrovascular disease, peripheral artery disease, and abdominal aortic aneurysm and (2) nonatherosclerotic cardiovascular disease phenotypes, stratified by ancestry.
Methods: We performed (1) Mendelian randomization analyses for previously reported cardiovascular associations and (2) Mendelian randomization-phenome-wide association analyses for novel associations.