Publications by authors named "B Naliboff"
Objective: To assess differences in clinical presentation and illness impact in men and women presenting with urologic chronic pelvic pain syndrome (UCPPS) and between men diagnosed with interstitial cystitis/bladder pain syndrome (IC/BPS) or chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
Methods: 356 men and 605 women from six sites across the United States were assessed using a comprehensive set of demographic, symptom, and illness impact measures. Multivariable regression analyses examined differences between men and women and between men previously diagnosed with CP/CPPS or IC/BPS.
Pain clinical trials are notoriously complex and often inefficient in demonstrating efficacy, even for known efficacious treatments. A major issue is the difficulty in the a priori identification of specific phenotypes to include in the study population. Recent work has identified the extent of widespread pain as an important determinant of the likelihood of response to therapy, but it has not been tested in clinical trials for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the biological basis of stress reactivity (SR) differences in individuals, focusing on irritable bowel syndrome (IBS) patients and healthy controls (HCs) to understand how these differences impact their health.
- It uses data from 291 participants, applying methods like transcriptomics profiling and brain imaging to categorize individuals into high and low SR groups and analyze their differences.
- Results indicate that those with high SR have greater sympathetic nervous system activation and brain changes linked to heightened stress responses, suggesting that this increased activity could be a risk factor for IBS and may inform personalized treatment approaches.
Background Brainstem nuclei play a critical role in both ascending monoaminergic modulation of cortical function and arousal, and in descending bulbospinal pain modulation. Even though sex-related differences in the function of both systems have been reported in animal models, a complete understanding of sex differences, as well as menopausal effects, in brainstem connectivity in humans is lacking. This study evaluated resting-state connectivity of the dorsal raphe nucleus (DRN), right and left locus coeruleus complex (LCC), and periaqueductal gray (PAG) according to sex and menopausal status in healthy individuals.
View Article and Find Full Text PDFArticle Synopsis
- Adverse childhood experiences (ACE) are linked to a higher risk of irritable bowel syndrome (IBS), which affects more women than men, but both genders show similar ACE prevalence related to IBS.* -
- A study with 798 participants found that individuals with IBS had more ACE, with emotional abuse increasing IBS odds in women and sexual abuse in men.* -
- Anxiety significantly mediated the relationship between ACE and IBS for both sexes, while resilience played a role only for women, highlighting the importance of mental health factors in this association.*