The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export.

Canonical RAS signaling, including PI3K/AKT- and RAF/MEK-dependent activities, results mainly from RAS•GTP interaction with its effectors at the plasma membrane. Here, we identified a fundamental, oncogenic, noncanonical RAS•GTP activity that increases XPO1-dependent export of nuclear protein cargo into the cytoplasm and is independent of PI3K/AKT and RAF/MEK signaling. This RAS-dependent step acts downstream from XPO1 binding to nuclear protein cargo and is mediated by a perinuclear protein complex between RAS•GTP and RanGAP1 that facilitates hydrolysis of Ran•GTP to Ran•GDP, which promotes release of nuclear protein cargo into the cytoplasm.

Encapsulation Engineering of Sulfur into Magnesium Oxide for High Energy Density Li-S Batteries.

This study addresses the persistent challenge of polysulfide dissolution in lithium-sulfur (Li-S) batteries by introducing magnesium oxide (MgO) nanoparticles as a novel additive. MgO was integrated with sulfur using a scalable process involving solid-state melt diffusion treatment followed by planetary ball milling. XRD measurements confirmed that sulfur (S) retains its orthorhombic crystalline structure (space group Fddd) following the MgO incorporation, with minimal peak shifts indicating slight lattice distortion, while the increased peak intensity suggests enhanced crystallinity due to MgO acting as a nucleation site.

Does unintended birth lead to zero dose of DPT vaccine among children aged 12-23 months in India?

Zero-dose children pose a key challenge in immunization programs due to their association with access to the health system and primary healthcare services. Examining zero-dose aids an in-depth understanding of healthcare disparities among children and caregivers. The disparity in utilization of maternal and child health services raises concerns about the potential consequences of unintended pregnancies on vaccine uptake.

Contributions of the Dachsous intracellular domain to Dachsous-Fat signaling.

The protocadherins Fat and Dachsous regulate organ growth, shape, patterning, and planar cell polarity. Although Dachsous and Fat have been described as ligand and receptor, respectively, in a signal transduction pathway, there is also evidence for bidirectional signaling. Here, we assess signaling downstream of Dachsous through analysis of its intracellular domain.