[Nicotinamide in combined treatment of chronic pancreatitis].

Aim: To evaluate effects of nicotinamide on insulin secretion in glucose tolerance test and on blood clotting in patients with chronic pancreatitis (CP).

Materials And Methods: 30 patients with CP of alcoholic etiology received combined treatment with enzyme medicines. In addition, some of them were administered nicotinamide as 2.

[Activities of glutathione enzymes in liver biopsy specimens in chronic lesions of hepatocytes].

The nonenzymatic conjugation of metabolites is decreased in chronic diseases of the liver, which is caused by decreased concentration of glutathione. The activities of glutathione enzymes are increased, this indicating the development of compensatory processes of mobilization of the second phase of detoxication, that is, increased conjugation under conditions of suppression of the cytochrome P-450 system. Measurement of liver glutathione transferase is a highly informative test for assessing the activity of the pathological process, particularly important in patients with chronic active hepatitis and cirrhosis of the liver.

[Cholestasis assessment by activity of antioxidant enzymes and composition of plasma lipoproteins in patients with liver diseases].

Aim: Investigation of activity of copper-containing enzymes in plasma superoxide dismutase (SOD) and ceruloplasmin (CP) in comparison with concentrations of lipoproteins (LP) of the main classes in patients with chronic hepatic diseases (CHD).

Materials And Methods: SOD activity, CP and LP in plasma were measured in 90 patients with CHD.

Results: An inverse relationship was found between SOD activity and CP content in CHD.

[Cytochrome P-450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in chronic liver diseases].

Repression of cytochrom P-450-dependent hydroxylation and demethylation in liver was demonstrated in bioptats of patients with chronic liver diseases. The inhibition of cytochrome P450 system was provoked by oxidative modification of proteins-enzymes in patients with chronic liver changes as was proposed at the same time. The activation of glutathione-dependent enzymes was revealed.

[The clinical significance of the liver glutathione system in chronic lesions].

It is shown that chronic hepatobiliary pathology is associated with a fall in spontaneous metabolite conjugation related to reduced concentration of hepatic glutathione. There was also enhanced activity of glutathione-dependent enzymes. This indicates progress of compensatory processes associated with mobilization of detoxication phase 2, i.