[Indices of cerebrovascular reactivity in patients with diabetes mellitus complicated with cardiovascular autonomic neuropathy].

Objectives: To investigate cerebrovascular reactivity in patients with diabetes mellitus complicated with cardiovascular autonomic neuropathy.

Methods: We examined 34 patients with diabetes mellitus (9 men and 25 women). Functional tests (hypercapnic, cold, orthostatic and others) and indices of cerebral hemodynamics were used for the evaluation of cerebrovascular reactivity.

[The level of circulating cytokines and chemokines in the preclinical and early clinical stages of type IA diabetes mellitus development].

Aim: to study the level of circulating proinflammatory (IL-1alpha, IL-1beta, IL-6, alpha-TNF, IFN-gamma) and anti-inflammatory (IL-4, IL-10) cytokines and chemokines (IL-8, IL-16) in preclinical development of type 1A diabetes mellitus (T1DM) in children.

Subjects And Methods: An examination was made in 450 children who had normal blood glucose levels and a burdened history of positive or negative Langerhans islet autoantibodies (LIAA): IAA, GADA, and 1A-2A over time until the clinical manifestations of DM1 emerged. The levels of the cytokines and chemokines were determined by ELISA and the titer of LIAA was by radioimmunoassay.

[The immunity during the pre-clinical period of type I diabetes mellitus].

The purpose of the study was to investigate the condition of immunity (blood lymphocyte immune phenotype and ultrastructure) in healthy children with a family background of type 1 diabetes mellitus (DM 1) having or not having diabetes-associated autoantibodies (DAAB). The subjects of the study were divided into three groups. Group 1 consisted of 90 children with a family background of DM 1 (first line relatives had DM 1), DAAB- (GADA, IA-2A, and IAA) positive or negative; group 2 consisted of 51 children with newly revealed DM 1; group 3 included 45 healthy controls, normoglycemic DAAB-negative children with no family background of DM 1.

[Prevalence and risk factors for the development of diabetic neuropathy].

Neuropathology is one of the most commonly encountered complications of diabetes mellitus. But we are lacking in exact estimates of the nervous system affliction incidence rates in patients with diabetes mellitus in countries of the Commonwealth of Independent States. Our objective in this work was to study prevalence of diabetic neuropathy and to identify factors predisposing to formation of the above complication of diabetes in the Prednistrovye Region of Moldova.

[Considerable decrease in chemokine interleukin-16 level in blood of children with diabetes mellitus type I diagnosed for the first time].

Considerable decrease in chemokine interleukin-16 level has been detected in blood serum of children with the first diagnosed in life diabetes mellitus type I.