Microbiological Profile of Periprosthetic Joint Infections: A Retrospective Analysis from North India.

With the rise in total joint arthroplasties, prosthetic joint infections (PJIs) have become a significant complication, leading to high morbidity. The causative organisms of PJIs vary by region, and the rates of drug-resistant organisms are growing, thus complicating the initial empiric choice of antibiotics. This retrospective study analyzed records of patients with orthopedic implants and intraoperative tissue samples sent for sonication and culture at a tertiary care hospital in India.

Design and Synthesis of Benzimidazole Carboxamide Cysteine Protease Inhibitors as Promising Anti-leishmanial Agents.

Introduction: More than 20 protozoan species of Leishmania are responsible for causing Leishmaniasis, an infection spread by blood-feeding phlebotomine sandflies. A narrow pool of drugs is currently available rendering the current drug stratagem to treat this infection . Development of novel, less toxic, and more effective regimens is thus a need of the hour.

Macrolide and fluoroquinolone resistance associated mutations in Mycoplasma genitalium in men who have sex with men attending STI clinic: A pilot study from India.

Background Increasing rates of macrolide and fluroquinolone resistance in Mycoplasma genitalium (MG) are being reported worldwide with resultant treatment failure. Aim We aimed to determine the level of antibiotic resistance of MG in men who have sex with men (MSM) attending a sexually transmitted infections (STIs) clinic in New Delhi, India. Methods Real-time polymerase chain reaction (PCR) assays targeting MgPa and pdhD genes were performed to detect MG rectal, urogenital or oropharyngeal infections in 180 MSM between January 2022 and June 2023.