Publications by authors named "B N Burkett"
Quantum error correction (QEC) provides a practical path to fault-tolerant quantum computing through scaling to large qubit numbers, assuming that physical errors are sufficiently uncorrelated in time and space. In superconducting qubit arrays, high-energy impact events can produce correlated errors, violating this key assumption. Following such an event, phonons with energy above the superconducting gap propagate throughout the device substrate, which in turn generate a temporary surge in quasiparticle (QP) density throughout the array.
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- The study examines the low tumor doses achieved in non-prostate cancers treated with [Lu]Lu-PSMA radioligand, using a case of renal cell carcinoma as an example.
- Despite high uptake of the imaging agent [Ga]Ga-PSMA-11, treatment with [Lu]Lu-PSMA-I&T resulted in low radiation doses to tumors (0.2-0.5 Gy) and no observable treatment effect.
- The researchers suggest that the ineffective targeting may be due to PSMA receptors being located on new blood vessels rather than on tumor cells, leading to rapid washout; they propose using a radionuclide with a shorter half-life to improve treatment efficacy.
Undesired coupling to the surrounding environment destroys long-range correlations in quantum processors and hinders coherent evolution in the nominally available computational space. This noise is an outstanding challenge when leveraging the computation power of near-term quantum processors. It has been shown that benchmarking random circuit sampling with cross-entropy benchmarking can provide an estimate of the effective size of the Hilbert space coherently available.
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- The gastrin-releasing peptide receptor (GRPr) is being studied as a potential diagnostic and therapeutic target for various cancers, particularly in detecting intra-prostatic prostate cancer (PCa) lesions using [Ga] Ga-GRPr PET imaging.
- A systematic review analyzed data from 9 studies with 291 patients, finding that [Ga] Ga-GRPr PET imaging had detection rates of 87.09% for overall patients and 89.01% for those with Gleason scores of 7 or higher, while per-lesion detection rates were 78.54%.
- The detection rate for multiparametric MRI (mpMRI) was slightly higher at 91.85%, but the difference compared to [Ga