[Efficacy of levofloxacin, lomefloxacin and moxifloxacin vs. other fluoroquinolones in experimental plague due to FI+ and FI- strains of Yersinia pestis in Albino mice].

Activity of levofloxacin, lomefloxacin and moxifloxacin against 20 FI+ and 20 FI- strains of Yersinia pestis was studied. It was shown that the strains were highly susceptible to the fluoroquinolones. In the experiments on mice subcutaneously infected with suspension of strains 231 FI+ and 231 FI- of Y.

High-sensitivity express immunochromatographic method for detection of plant infection by tobacco mosaic virus.

A highly sensitive express immunochromatography method for molecular diagnosis of plant virus infections was elaborated on the example of a model object - tobacco mosaic virus (TMV). The analysis time does not exceed 5 min, and the lower limit of TMV detection in non-clarified leaf extract (2-4 ng/ml) is comparable with the sensitivity of the enzyme-linked immunosorbent assay of the virus. A single measurement requires 0.

[Infectious-toxic model of plague in mice].

Aim: To develop infectious-toxic model of plague in mice and to assess perspectives of its use for selection of new vaccine preparations.

Materials And Methods: Cells of virulent strains of Yersinia pestis 231 and 231 FI- incubated in lysates of human erythrocytes for their activation as well as suspensions of these strains in isotonic solution of NaCl were used for subcutaneous inoculation of infection-nanve and immune mice.

Results: It was shown that activated cultures were characterized by maximal virulence (LD50 = 1-3 CFU) and caused rapid infection--mean length of survival reduced on 1 - 3 days (P < or = 0.

pH-Metric determination of acid values in oilseeds without titration.

A new pH-metric method for determination of acid values in oilseeds without titration has been developed in the range 0.6-10 and more mg KOH/g. The method is based on a rapid (1-2 min) selective and complete extraction of free fatty acids from an oilseed test portion into a special reagent A, separation of the solution from the solid oilseed material by centrifugation or filtration, transfer of an aliquot of the solution into a pH-metric cell with reagent B for measurement of conditional pH(1)' of the formed mixture, addition of standard acid (HCl or H(2)SO(4)) and pH(2)' measurement.

[The combined action of octafluoropropane and bipolar ionized air].

An experiment with Wistar male rats was to look into the action of octafluoropropane (OFP, of 50 microg/m(3)) combined with bipolar ionized air (BIA) at a concentration of light air ions of 60,000 para-air in cm(3). The chamber experiment was 43 days long. Intoxication by OFP reduced body mass, as well as the erythrocyte count and hemoglobin level in peripheral blood.