Publications by authors named "B Myhre Dupuy"
Clinical symptoms of infection (CDI) range from diarrhea to pseudomembranous colitis. A major challenge in managing CDI is the high rate of relapse. Several studies correlate the production of CDT binary toxin by clinical strains of with higher relapse rates.
View Article and Find Full Text PDFAdaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota.
NPJ Biofilms Microbiomes
September 2024
Article Synopsis
- * Research investigated how bacteria might develop resistance to AF, focusing on the role of the thioredoxin reductase enzyme (TrxB) and its multiple forms in clinical strains, though the number of TrxB genes didn't affect AF's minimum inhibitory concentration (MIC).
- * Mutations that arose after long-term exposure to AF were found in an anti-sigma factor, impacting bacterial physiology, and AF was shown to have a lesser effect on human gut microbiota compared to the antibiotic vancomycin.
Clostridioides difficile causes a wide range of intestinal diseases through the action of two main cytotoxins, TcdA and TcdB. Ingested spores germinate in the intestine establishing a population of cells that produce toxins and spores. The pathogenicity locus, PaLoc, comprises several genes, including those coding for TcdA/B, for the holin-like TcdE protein, and for TcdR, an auto-regulatory RNA polymerase sigma factor essential for tcdA/B and tcdE expression.
View Article and Find Full Text PDFis an anaerobic spore-forming bacterium genetically related to but lacks toxin genes. The sporulation mechanism and spore structures of anaerobic bacteria, including , have not been comprehensively analyzed. Based on 16S rRNA gene analysis, it has been determined that NBRC 14293 belongs to Group I.
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