[Evaluation of pulmonary function in children of preschool age treated in the neonatal period with distension methods].

Within the framework of a long-term follow up of the development of neonates with low birth-weight the authors investigated pulmonary functions in a group of 20 children aged 5.5 years treated during the neonatal period on account of early asphyctic syndrome, hyaline membrane syndrome and bronchopulmonary dysplasia by the distension method, using a continual positive pressure. The birth-weight of the investigated children varied between 600 and 1500 g.

[Immunologic reactivity of tylosin and erythromycin].

The authors investigated the antibody response to erythromycin and tylosine in experiments and in a clinical investigation. The results proved in 90-100% a crossed immunological reactivity of the two macrolid antimicrobial preparations. In view of the wide use of tylosine in veterinary practice and its presence in residues of slaughter animals as well as in serological tests, it is very probable that this preparation participates in a major way in the increased incidence of allergic reactions against erythromycin in humans.

[Use of prostanoids in the diagnosis and treatment of bronchial reactivity in children].

The bronchoconstrictive effect of prostaglandin F2 alpha was investigated in 24 school children suffering from obstructive lung disease. In all the investigated substance was administered by 2-minute inhalation, consecutively in doses of 0.06-0.

[Immunologic aspects of macrolide antibiotics].

The authors investigated in an experimental and clinical study the part played by the macrolide antibiotic, tylosine, in the elevated immunological reactivity of the present population to Erythromycin. The first assembled results justify the statement that tylosine used in veterinary practice (sometimes without control) may indice acrossed immunological reactivity against Erythromycin. The authors discuss also other undesirable manifestations after Erythromycin administration.