Publications by authors named "B Mouridsen"
Needle-based injections currently enable the administration of a wide range of biomacromolecule therapies across the body, including the gastrointestinal tract, through recent developments in ingestible robotic devices. However, needles generally require training, sharps management and disposal, and pose challenges for autonomous ingestible systems. Here, inspired by the jetting systems of cephalopods, we have developed and evaluated microjet delivery systems that can deliver jets in axial and radial directions into tissue, making them suitable for tubular and globular segments of the gastrointestinal tract.
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- Oral drug administration is typically limited by poor absorption and quick breakdown in the digestive system, necessitating injections for effective delivery.
- A new orally dosed liquid auto-injector has been developed, allowing for up to 4 mg doses of a bioavailable drug with injection-like absorption rates and achieving up to 80% bioavailability in just 30 minutes.
- Tests on swine show this method effectively delivers clinically relevant doses of commonly injected drugs, highlighting its potential for real-world medical applications.