Publications by authors named "B Morawski"
Background: The Oncotype DX Genomic Prostate Score (ODX-GPS) is a gene expression assay that predicts disease aggressiveness. The objective of this study was to identify sociodemographic and regional factors associated with ODX-GPS uptake.
Methods: Data from Surveillance Epidemiology and End Results registries on men with localized prostate cancer with a Gleason score of 3 + 3 or 3 + 4, PSA ≤20 ng/mL, and stage T1c to T2c disease from 2013 through 2017 were linked with ODX-GPS data.
Reporting tumor genomic test results to SEER registries via linkages.
J Natl Cancer Inst Monogr
August 2024
Article Synopsis
- Precision medicine is increasingly important in cancer care, but tumor genomic data has been lacking in the National Cancer Institute's SEER Program, limiting research on molecular subtypes.
- To improve this, the SEER Program has implemented a centralized process to link cancer cases in their registries with genomic test results from molecular labs, using specialized software and a trusted third party for data handling.
- Recent linkages have included various OncotypeDX tests and results from other genomic classifiers, which facilitate the research community's access to valuable, de-identified data for cancer studies.
Article Synopsis
- Immunosuppressed individuals, such as those with HIV and solid organ transplant recipients, face a higher risk of developing certain cancers, prompting a study to identify specific cancer types associated with these conditions.* -
- Researchers analyzed cancer registry data in the U.S., finding a total of 38,047 cancer cases among organ transplant recipients and 53,592 among individuals with HIV, with elevated standardized incidence ratios of 1.66 and 1.49 respectively.* -
- Specific cancers, like conjunctival squamous cell carcinoma, showed significantly higher risks in both populations, while others, such as sebaceous adenocarcinoma, were particularly heightened in solid organ transplant recipients, emphasizing the need for awareness and monitoring in these
Background: Certain workers are at increased risk for acquiring Legionnaires' disease compared with other workers. This study aims to identify occupations at increased risk for acquiring Legionnaires' disease.
Methods: Using data from the US Centers for Disease Control and Prevention's Supplemental Legionnaires' Disease Surveillance System, this study identified Legionnaires' disease confirmed patients ≥16 years of age in 39 states with reported symptom onset during 2014-2016.
Article Synopsis
- Adults with HIV-associated cryptococcal meningitis frequently have concurrent infections with cytomegalovirus (CMV) and tuberculosis (TB), which can complicate their health outcomes.
- A study of 497 Ugandan patients revealed that 42% either developed TB or died within a median follow-up of 4.6 months, with a notable risk increase linked to high levels of CMV viremia at diagnosis.
- Specifically, participants with high CMV viremia (≥1000 IU/mL) were more than twice as likely to experience TB or death compared to those with lower or no detectable CMV levels.