[A case of Alzheimer's disease simulating Creutzfeldt-Jakob disease].

A case of Alzheimer's disease simulating Creutzfeldt-Jakob disease--We report here a case of 67-year old man with frank dementia accompanied by extrapyramidal syndrome and myoclonic jerks. The diagnosis of Creutzfeldt-Jakob disease was suggested but the neuropathological examination revealed features most compatible with Alzheimer's disease. The "gray area" between both cerebral amyloidoses was discussed.

Expression of tumor necrosis factor-alpha cachectin in primary brain tumors of astrocytic lineage.

The tumor necrosis factor alpha (TNF-alpha) is a cytokine released within central nervous system from activated astrocytes and macrophages and involved in several pathologic processes including AIDS-myelopathy, multiple sclerosis and myelin dilatation in panencephalic type of Creutzfeldt-Jakob disease. We studied the expression of the TNF-alpha in brain tumors. Only tumors of astrocytic lineage like astrocytomas and glioblastomas, or tumors of mixed lineage as oligo-astrocytomas and multipotential primitive neuroectodermal tumors (PNET) expressed TNF-alpha-like immunoreactivity.

Neuroblastic differentiation of metastases of medulloblastoma to extracranial lymph node: an ultrastructural study.

Extracranial metastases of a poorly differentiated medulloblastoma in a 12-year-old girl were studied by thin section transmission electron microscopy and immunohistochemistry. The primary tumor did not show any differentiation as revealed by immunohistochemistry. On the contrary, the metastatic tumor cells and their processes disclosed features of neuroblastic differentiation when examined ultrastructurally: microtubules, dense core vesicles, and abortive synaptic ribbons.

PrP amyloid plaques in Creutzfeldt-Jakob disease of short duration: immunohistochemical studies of 5 cases from Poland.

We report here PrP-immunohistochemistry performed on brains from CJD cases from Poland. Only one of five definitive CJD cases exhibited typical PrP-immunoreactive kuru-like plaques and this was case of a short duration. We thus confirm the low frequency of PrP plaques in CJD of Eastern and Central European origin.

Creutzfeldt-Jakob disease (CJD) of a short duration with prion protein (PrP) plaques.

We report here PrP-immunohistochemistry performed on brains from CJD cases from Poland. Only one out of five definitive CJD cases exhibited typical PrP-immunoreactive kuru-like plaques and this was case of a short duration. Thus, we confirmed the low percentage of PrP plaques in CJD of Eastern and Central European origin.