Publications by authors named "B Miralles-Perez"

Urban environments are usually polluted by anthropogenic activities like traffic, a major source of potentially toxic elements (PTEs), and ornamental plant species may reduce contamination by trapping traffic-related air pollutants in their leaves. The purpose of this study was tested the trapping pollutant capacity of four species commonly used in green areas of Seville city (SW Spain) to better choose species in urban green planning. Composition of particulate matter (PM) obtained from foliar surfaces (sPM) and wax-included (wPM) was determined by EDX-SEM analysis in samples from different city locations.

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  • ω-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), are vital for brain health, but excessive DHA can lead to oxidative stress in the brain.
  • A study on male rats showed that a 10-week diet with high-DHA fish oil improved antioxidant defenses and reduced protein carbonylation in brain regions compared to oils with lower DHA levels.
  • Findings revealed that the cerebellum is more affected by dietary fat composition than the cortex, suggesting that high DHA intake enhances the brain's ability to cope with oxidative damage.
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  • Diets high in saturated fats and sugars lead to oxidative stress, which can cause cognitive decline and aging of the brain, especially in the cerebellum.
  • The study conducted on rats found that such diets increased the carbonylation of proteins related to energy metabolism and neurotransmitter functions in the cerebellum over 21 weeks.
  • Supplementing with fish oil reduced oxidative damage by protecting against protein carbonylation and may suggest a dietary solution to improve cerebellar health.
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High daily intake of saturated fats and refined carbohydrates, which often leads to obesity and overweight, has been associated with cognitive impairment, premature brain aging and the aggravation of neurodegenerative diseases. Although the molecular pathology of obesity-related brain damage is not fully understood, the increased levels of oxidative stress induced by the diet seem to be definitively involved. Being protein carbonylation determinant for protein activity and function and a main consequence of oxidative stress, this study aims to investigate the effect of the long-term high-fat and sucrose diet intake on carbonylated proteome of the cerebral cortex of Sprague-Dawley rats.

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  • Obesity increases the risk of chronic kidney disease, with insulin resistance being a common early symptom; this study explores how a diet high in fat and sugar affects kidney function and insulin sensitivity in rats.
  • The research found that rats on this diet showed signs of prediabetes and kidney dysfunction, characterized by higher levels of plasma urea and increased fat accumulation in the kidneys, particularly saturated fats and specific fatty acids.
  • Supplementation with fish oil and buckwheat D-Fagomine demonstrated potential benefits by reducing kidney fat toxicity, improving lipid profiles, and mitigating protein changes linked to insulin resistance, thus slowing down the progression of kidney disease and prediabetes.
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