Publications by authors named "B Meibohm"

The TRPC3 protein plays a pivotal role in calcium signaling, influencing cell function. Aberrant TRPC3 expression is implicated in various pathologies, including cardiovascular diseases, tumors, and neurodegeneration. Despite its functional similarities with TRPC6 and TRPC7, TRPC3 exhibits distinct roles in disease contexts.

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Objective: To evaluate age, adjunctive antiseizure medication (ASM), and specific ASMs on lacosamide (LCM) weight normalized dose-to-concentration ratio (DCR) and US Food and Drug Administration (FDA) dosing guidelines in pediatric patients.

Methods: Patients 1 mo to ≤18 years with a LCM serum concentration between October 2009 and June 2017 were considered. Demographics, LCM DCR, and adjunctive ASM were recorded.

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Article Synopsis
  • The Nix-TB clinical trial tested a new 6-month TB treatment called the BPaL regimen, which includes bedaquiline, pretomanid, and linezolid, achieving a 90% cure rate in drug-resistant TB patients, but caused severe side effects due to linezolid.
  • Researchers propose substituting linezolid with inhaled spectinamide 1599 to create the BPaS regimen, which shows similar effectiveness as the BPaL regimen while reducing adverse events.
  • In animal studies, the BPaS regimen demonstrated equivalent bactericidal effects with fewer side effects like weight loss and anemia compared to BPaL, suggesting inhaled spectinamide has a superior safety profile in
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Article Synopsis
  • Scientists created new medicines called spectinamides to help treat tuberculosis (TB) more effectively.
  • One of these, named MBX-4888A, works well with other TB drugs like rifampin and pyrazinamide in mice.
  • The research showed that using MBX-4888A can help shorten the treatment time for TB and seems to be safe for long-term use in mice.
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Background And Purpose: Bifunctional small molecule degraders, which link the target protein with E3 ubiquitin ligase, could lead to the efficient degradation of the target protein. BGB-16673 is a Bruton's tyrosine kinase (BTK) degrader. A translational PK/PD modelling approach was used to predict the human BTK degradation of BGB-16673 from preclinical in vitro and in vivo data.

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