Publications by authors named "B Meder"
Article Synopsis
- A study on 325 pulmonary arterial hypertension (PAH) patients found mutations in 23% using a specific gene panel targeting 18 known PAH genes.
- Additional sequencing identified two variants in the SMAD5 gene, which were further characterized through various functional tests, confirming their expression and effects on cell behavior.
- One variant was linked to a familial history of PAH and resulted in increased cell viability, while the other variant, associated with congenital heart disease, led to reduced cell viability due to increased apoptosis; both were deemed likely pathogenic and indicate SMAD5 as a potential new PAH gene for diagnostic testing.
Article Synopsis
- * A large study involving nearly 10,000 DCM cases and close to a million controls identified 70 significant genetic locations linked to the disease, revealing the importance of heart muscle cells in its development.
- * The research also indicates that factors like higher body weight and blood pressure may contribute to DCM, and genetic risk scores can help predict the condition across different populations.
Patent foramen ovale (PFO) is a congenital heart defect affecting up to 25% of the population, associated with an increased risk of cryptogenic stroke. Percutaneous PFO closure is a minimally invasive procedure aimed at reducing stroke risk by eliminating the right-to-left shunt. This monocentric, retrospective study analyzed 716 patients who underwent PFO closure between January 2000 and February 2023.
View Article and Find Full Text PDFGeneralization, defined as applying limited experiences to novel situations, represents a cornerstone of human intelligence. Our review traces the evolution and continuity of psychological theories of generalization, from its origins in concept learning (categorizing stimuli) and function learning (learning continuous input-output relationships) to domains such as reinforcement learning and latent structure learning. Historically, there have been fierce debates between approaches based on rule-based mechanisms, which rely on explicit hypotheses about environmental structure, and approaches based on similarity-based mechanisms, which leverage comparisons to prior instances.
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