Publications by authors named "B Matuszczak"
Chitosan (Ch) and different Ch derivatives have been applied in tissue engineering (TE) because of their biocompatibility, favored mechanical properties, and cost-effectiveness. Most of them, however, lack cell adhesive properties that are crucial for TE. In this study, we aimed to design an S-protected thiolated Ch derivative exhibiting high cell adhesive properties serving as a scaffold for TE.
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- * Traditional NSAIDs can have side effects by disrupting the production of beneficial compounds, but new multi-target inhibitors like diflapolin offer potential improved efficacy and safety despite challenges with solubility and bioavailability.
- * Researchers have designed new derivatives using thiazolopyridines to enhance solubility and target specific enzymes; one such derivative effectively inhibits lipid mediators while also reducing thromboxane production, suggesting a promising strategy for broadening treatment applications.
A series of derivatives of the potent dual soluble epoxide hydrolase (sEH)/5-lipoxygenase-activating protein (FLAP) inhibitor diflapolin was designed, synthesised, and characterised. These novel compounds, which contain a benzimidazole subunit were evaluated for their inhibitory activity against sEH and FLAP. Molecular modelling tools were applied to analyse structure-activity relationships (SAR) on both targets and to predict solubility and gastrointestinal (GI) absorption.
View Article and Find Full Text PDFInvasive pulmonary aspergillosis (IPA) is a life-threatening form of fungal infection, primarily in immunocompromised patients and associated with significant mortality. Diagnostic procedures are often invasive and/or time consuming and existing antifungals can be constrained by dose-limiting toxicity and drug interaction. In this study, we modified triacetylfusarinine C (TAFC), the main siderophore produced by the opportunistic pathogen (), with antifungal molecules to perform antifungal susceptibility tests and molecular imaging.
View Article and Find Full Text PDFAim: The aim was to develop a self-emulsifying drug delivery system (SEDDS) for amikacin via imine bond formation with hydrophobic aldehydes.
Methods: Trans-2, cis-6-nonadienal, trans-cinnamaldehyde, citral and benzaldehyde were conjugated to amikacin at pH 8.5.