Publications by authors named "B Matti"
Article Synopsis
- The study aimed to evaluate how PSA testing rates impact prostate cancer diagnosis and mortality in Māori men in New Zealand.
- Over 63,000 Māori men were analyzed, revealing higher prostate cancer diagnosis and better survival rates among those who underwent regular PSA testing compared to those who did not.
- The findings suggest that increased frequency of PSA testing could significantly enhance cancer survival rates in Māori men, indicating a need for prioritizing regular testing in this population.
Article Synopsis
- The B cell receptor (BCR) signaling pathway is vital for B cell development and is also involved in the progression of B cell cancers, leading to continuous activation of Bruton tyrosine kinase (BTK), enhancing survival and growth of malignant cells.
- BTK inhibitors (BTKi), like ibrutinib and acalabrutinib, effectively treat several types of B cell malignancies by permanently blocking BTK, but many patients may relapse due to resistance mechanisms, including mutations at the BTK binding site.
- Newer approaches, such as non-covalent BTKi (like pirtobrutinib) and proteolysis-targeting chimeras (PROTACs), have shown promise in overcoming
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Despite its indolent clinical course, therapy refractoriness and disease progression still represent an unmet clinical need. Before the advent of pathway inhibitors, chemoimmunotherapy (CIT) was the commonest option for CLL treatment and is still widely used in areas with limited access to pathway inhibitors.
View Article and Find Full Text PDFThe key cell population permits cancer cells to avoid immune-surveillance is regulatory T cells (Tregs). This study evaluates the level of Tregs in chronic myeloid leukemia (CML) patients and the effect of Tyrosine kinase inhibitor (TKI) on Treg levels, as a pathway to understand the immune response and behavior among advance stage and optimal response CML patients using imatinib therapy. Blood samples were collected from 30 CML patients (optimal response to TKI), 30 CML patients (failure response to TKI), and 30 age- and gender-matched controls.
View Article and Find Full Text PDFObjectives: To systematically evaluates the evidence on ethnic differences in age-adjusted reference values of PSA.
Materials And Methods: In concordance with the Preferred Reporting Items for Systematic Review and Meta-analysis statement, a review of English articles using Medline, Embase and Cochrane databases, from inception to December 2019 was conducted. Studies that reported the PSA upper reference value as 95th percentile of the cohort distribution, in healthy men aged 40 to 79, were included.