Publications by authors named "B Matthew Hicks"
Concerns have been raised that glucagon-like peptide 1 receptor agonists (GLP1-RAs) may increase the risk of thyroid cancer, but evidence remains conflicting. We therefore investigated if GLP1-RA use, compared with use of dipeptidyl peptidase-4 inhibitors (DPP-4is), was associated with thyroid cancer risk in patients with type 2 diabetes. This multisite cohort study with subsequent meta-analysis included six population-based databases from Canada (Ontario), Denmark, Norway, South Korea, Sweden, and Taiwan.
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- * Results showed that a higher PRS was more strongly related to EGFR-positive LUAD cases (OR=8.63) than to EGFR-negative cases (OR=3.50), indicating a significant association based on mutation status.
- * These findings imply that genetic susceptibility to LUAD differs in never-smoking East Asian women depending on whether the cancer has specific mutations, which could affect public health strategies and clinical practices.*
Article Synopsis
- Normal tissues adjacent to breast tumors (NATs) may contain early signs of breast cancer development due to a phenomenon called field cancerization.
- A study using advanced genomic techniques on samples from 43 breast cancer patients in Hong Kong revealed that NATs often had single-nucleotide variants (SNVs) in driver genes also found in tumor samples, but rarely had large-scale genomic changes.
- The researchers identified different evolutionary patterns among NAT and tumor pairs, indicating distinct genomic characteristics and the influence of the tumor microenvironment on cancer development.