Publications by authors named "B Matard"
Article Synopsis
- Folliculitis decalvans is a chronic condition causing hair loss and is difficult to treat, with no current approved therapies available.
- This pilot study investigated the effects of anti-tumour necrosis factor-α (TNF-α) inhibitors on patients with treatment-resistant folliculitis decalvans, assessing their efficacy using a specially designed Investigator's Global Assessment (IGA) score.
- Out of 11 patients treated with infliximab or adalimumab over 12 months, 5 showed good response rates, indicating potential benefits from TNF-α inhibitors; however, more research is needed for validation.
Article Synopsis
- The study presents 30 cases of folliculitis decalvans (FD) observed in patients with dystrophic epidermolysis bullosa (DEB) among 125 DEB patients treated in French centers from 2010 to 2021.
- It suggests a potential physiological connection between the two rare diseases, indicating that the skin abnormalities present in DEB may exacerbate the occurrence of FD.
- The paper emphasizes the importance of this association for understanding the causes of FD, particularly highlighting the role of skin barrier dysfunction in these patients.
Folliculitis decalvans (FD) is a chronic inflammatory disease of unknown aetiology. Although Staphylococcus aureus, frequently found on lesional skin, is thought to play a causal role, the importance of its involvement remains controversial. To examine the role of S aureus, we compared superficial and subepidermal microbiota in 20 FD patients who had S aureus on lesional skin and in 20 healthy controls using culture techniques and genomic identification, before and after an anti-staphylococcal treatment; we also screened for S aureus virulence factors.
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