Publications by authors named "B Martinez-Garcia"
DNA supercoiling in biological systems can occur via three mechanisms. The first is by the activity of DNA topoisomerases, such as DNA gyrases, that can increase or reduce the linking number of relaxed DNA (Lk). The second is via DNA translocation motors, such as RNA and DNA polymerases, that produce twin supercoiled DNA domains: one positively supercoiled in front and one negatively supercoiled behind.
View Article and Find Full Text PDFIntroduction: This study aimed to describe and analyze the rate of clot migration of vessel thrombosis to distal segments in patients with acute ischemic stroke (AIS) who received intravenous thrombolysis (IVT) with tenecteplase (TNK) and alteplase (ALT) before mechanical thrombectomy (MT). In addition, we aimed to determine the relationship between thrombus migration and functional prognosis.
Methods: This study followed the STROBE reporting guidelines.
One elusive aspect of the chromosome architecture is how it constrains the DNA topology. Nucleosomes stabilise negative DNA supercoils by restraining a DNA linking number difference (∆Lk) of about -1.26.
View Article and Find Full Text PDFArticle Synopsis
- Scientists discovered that a special protein called Gcf1p helps organize mitochondrial DNA in a different way compared to similar proteins in humans and yeast.
- The research showed that Gcf1p can stick to DNA in unique ways, which helps it keep the DNA in a compact form without changing its structure.
- This study suggests that the way Gcf1p and other proteins work together is important for the survival of certain bad bacteria, like Candida albicans, which can resist antibiotics.
Condensin, an SMC (structural maintenance of chromosomes) protein complex, extrudes DNA loops using an ATP-dependent mechanism that remains to be elucidated. Here, we show how condensin activity alters the topology of the interacting DNA. High condensin concentrations restrain positive DNA supercoils.
View Article and Find Full Text PDF