Molecular basis of vitamin K driven γ-carboxylation at membrane interface.

The γ-carboxylation of glutamate residues enables Ca-mediated membrane assembly of protein complexes that support broad physiological functions including hemostasis, calcium homeostasis, immune response, and endocrine regulation. Modulating γ-carboxylation level provides prevalent treatments for hemorrhagic and thromboembolic diseases. This unique posttranslational modification requires vitamin K hydroquinone (KH) to drive highly demanding reactions catalyzed by the membrane-integrated γ-carboxylase (VKGC).

Simultaneous Unbinned Differential Cross-Section Measurement of Twenty-Four Z+jets Kinematic Observables with the ATLAS Detector.

Z boson events at the Large Hadron Collider can be selected with high purity and are sensitive to a diverse range of QCD phenomena. As a result, these events are often used to probe the nature of the strong force, improve Monte Carlo event generators, and search for deviations from standard model predictions. All previous measurements of Z boson production characterize the event properties using a small number of observables and present the results as differential cross sections in predetermined bins.

Long-term outcomes and resource Utilization related to upper extremity off-roading vehicle injuries.

Purpose: We aim to evaluate outcomes after off-roading injuries to determine their impact on patients' pain and function. Further, we aim to evaluate the burden on the healthcare system that result from these injuries.

Methods: Patients treated surgically for an off-roading injury at a single tertiary academic center completed surveys about their current level of upper extremity pain and function using QuickDASH and VAS-Pain scores.

The Displaced Fleck Sign: Description of a Radiographic Finding Consistent with Grade III Thumb Ulnar Collateral Ligament Tears with Stener Lesions.

Purpose: Controversy exists regarding the optimal imaging modality (magnetic resonance imaging, ultrasound, stress radiographs) for identification of patients with grossly unstable thumb metacarpophalangeal (MCP) ulnar collateral ligament (UCL) injuries or Stener lesions. We characterize a radiographic sign for this purpose. The "displaced fleck sign" is a small avulsion fracture from the ulnar proximal phalanx base that is displaced proximal to the MCP joint line.