Preliminary safety and in vivo efficacy of Acmella oleracea extract-loaded glycolipid emulsion serum-Effects on ocular irritation, dermal absorption, and facial skin biophysical and microrelief properties.

Objective: Substantial efforts have been progressively devoted to developing innovative, safe, and effective topical anti-aging products that not only improve the appearance of aged skin but also prioritize environmental sustainability and the responsible use of natural resources. Thus, the current study targeted to evaluate novel, natural emulsion/serum comprising new glycolipid emulsifier (lauryl glucoside/myristyl glucoside/polyglyceryl-6 laurate) and Acmella oleracea plant extract as a model active.

Methods: The developed serum was assessed concerning its stability (freeze-thaw test, accelerated study), safety (in vitro screening of eye irritation potential, dermal absorption study) and efficacy (randomized, active/reference-controlled, half-face, in vivo study).

In Vitro Evaluation of Pharmacokinetic Properties of Selected Dual COX-2 and 5-LOX Inhibitors.

Evaluation of pharmacokinetic properties is a significant step at the early stages of drug development. In this study, an in vitro evaluation of the pharmacokinetic properties of five newly synthesized compounds was performed. These compounds belong to N-hydroxyurea and hydroxamic acid derivatives and analogs of NSAIDs indomethacin, flurbiprofen, diclofenac, ibuprofen, and naproxen (compounds , , , and , respectively) with dual COX-2 and 5-LOX inhibitory activity.

Heyde Syndrome Unveiled: A Case Report with Current Literature Review and Molecular Insights.

Heyde syndrome, marked by aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome, is often underreported. Shear stress from a narrowed aortic valve degrades von Willebrand factor multimers, leading to angiodysplasia formation and von Willebrand factor deficiency. This case report aims to raise clinician awareness of Heyde syndrome, its complexity, and the need for a multidisciplinary approach.

Coal to Clean: Comparing Advanced Electrodes for Desulfurization and Copper Recovery.

Unlabelled: This study explores the electrochemical desulfurization of coal and the recovery of copper (Cu) using dimensionally stable anode (DSA) electrodes.

Background: The research addresses the need for effective sulfur removal from coal to reduce emissions.

Methods: Electrochemical desulfurization was conducted using DSA and graphite electrodes, evaluating parameters like activation energy, desulfurization rate, and energy consumption.

Synthesis and Antimicrobial Activity of Newly Synthesized Nicotinamides.

Antioxidants are promising compounds with antimicrobial activity against drug-resistant pathogens, especially when combined with conventional antimicrobials. Our study aimed to characterize the structure of nicotinamides synthesized from nicotinic acid and thiocarbohydrazones and to evaluate their antibacterial and antifungal activity. Seven nicotinic acid hydrazides (NC -) were synthesized using mono-thiocarbohydrazones with hydroxyl group substituents, along with quinolone, phenolic, and pyridine rings known for their antimicrobial activity.