Publications by authors named "B Marciano"
Article Synopsis
- New drugs targeting HER2-positive metastatic breast cancer have shown significant improvements in survival rates, but patients with brain metastases face poorer outcomes compared to those with other types of metastases.
- The prevention and treatment of brain metastasis are critical challenges that need to be addressed to enhance the quality of life and survival for these patients.
- The review explores the causes of brain metastasis, current treatment options, and prospective strategies for future therapies and diagnostics.
Background: The transition to adult health care is challenging for adolescents and young adults (AYA) with Chronic Granulomatous Disease (CGD). This pilot study aimed to facilitate the learning of AYA with CGD about their health care and to aid in the development of life skills to enhance self-care.
Methods: AYA and caregivers (for participants <18 years of age) completed an adapted Transition Readiness Assessment.
Article Synopsis
- Female carriers of X-linked chronic granulomatous disease (XL-CGD) can experience serious health issues like infections and inflammatory disorders.
- Although males are more commonly affected, female carriers still require regular medical assessments and preventive treatments as needed.
- Continued monitoring and proactive care are crucial for managing the health of female XL-CGD carriers.
Article Synopsis
- - Patients with GATA2 haploinsufficiency face higher risks for HPV-related anogenital cancers, with the study showing that HPV appeared at a median age of 18.9 in females and 25.6 in males, often leading to significant health issues.
- - The research conducted a thorough review of 68 patients over 17 years, revealing that 76% had HPV-related squamous intraepithelial lesions (SIL), with females showing a higher prevalence and severity of high-grade lesions compared to males.
- - Among patients receiving hematopoietic stem cell transplants for GATA2-linked diseases, some still experienced persistent HPV issues post-treatment; however, those who received vaccinations afterward showed minimal evidence
Background: Autoantibodies against interleukin-12 (anti-interleukin-12) are often identified in patients with thymoma, but opportunistic infections develop in only some of these patients. Interleukin-12 (with subunits p40 and p35) shares a common subunit with interleukin-23 (subunits p40 and p19). In a patient with disseminated infection, the identification of both anti-interleukin-23 and anti-interleukin-12 prompted further investigation.
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