Publications by authors named "B Mantilla"
Sets of electrophilic probes are generally prepared using a narrow toolkit of robust reactions, which tends to limit both their structural and functional diversity. A unified synthesis of skeletally-diverse sulfonyl fluorides was developed that relied upon photoredox-catalysed dehydrogenative couplings between hetaryl sulfonyl fluorides and hydrogen donor building blocks. A set of 32 diverse probes was prepared, and then screened against Trypanosoma brucei.
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- * Inositol phosphorylceramide (IPC) plays a key role in leishmania species, with IPC synthase (IPCS) being a critical enzyme; clemastine fumarate has emerged as a potential IPCS inhibitor and an anti-leishmanial agent.
- * Research reveals that while clemastine fumarate inhibits IPCS and alters metabolic pathways, its main action may involve different targets, suggesting further investigation is needed for effective treatment strategies.
is the causative agent of African trypanosomiasis, a deadly disease that affects humans and cattle. There are very few drugs to treat it, and there is evidence of mounting resistance, raising the need for new drug development. Here, we report the presence of a phosphoinositide phospholipase C (TbPI-PLC-like), containing an X and a PDZ domain, that is similar to the previously characterized TbPI-PLC1.
View Article and Find Full Text PDFObjective: Racial and ethnic disparities in rheumatoid arthritis (RA) disease activity measures have been documented. We compared racial and ethnic differences in disease activity using multiple composite measures, including an objective measure, the multi-biochemical disease activity (MBDA) score.
Methods: Data are derived from the University of California, San Francisco RA Cohort, a longitudinal observational cohort.