Publications by authors named "B Manikandan"

Antimicrobial peptides (AMPs) are gaining popularity as potential substitutes for conventional antibiotics and bio-preservatives in response to an increase in antimicrobial resistance cases. However, their poor pharmacokinetic profiles limit their applicability. This study using ADMETlab, OECD QSAR toolbox, and VEGA HUB virtual environments profiled 82 peptide sequences of seven bee antimicrobial peptides (BAMPs: abaecin, apamin, apisimin, apidaecin, defensin, hymenoptaecin, and melittin) using 81 descriptors combining physicochemical, medicinal chemistry, ADMET, and toxicophore criteria.

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Article Synopsis
  • Alzheimer's disease (AD) is linked to the buildup of harmful lipid molecules like 7-ketocholesterol (7KCh), which contribute to cell damage and amyloid-beta aggregation.
  • A study tested two natural compounds, bornyl acetate (BA) and menthol (ME), for their neuroprotective effects against 7KCh-induced damage in nerve cells, comparing their results to the drug galantamine (GA).
  • Findings revealed that BA and ME significantly reduced harmful effects like lipid accumulation and amyloid generation, improved cell survival, and regulated various biological pathways involved in inflammation and cell stress, showing promise as preventive treatments for AD.
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Phagocytosis by macrophages dates back to a long history in science, this present study deals with new approaches that have been analyzed and standardized towards the interesting aspects of primary and secondary macrophages. The distinct morphological differences in primary and secondary phagocytic cells were observed and the phagocytic response of secondary macrophages under the influence of 7-ketocholesterol and lipopolysaccharide was analyzed. The primary peritoneal and secondary IC-21 cells unveiled explicit differences in nuclear numbers shapes and sizes of the granules present within the cytoplasmic region.

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Infection-related glomerulonephritis (IRGN) is an immunologically mediated glomerular injury triggered by an extrarenal infection. Infective endocarditis-associated glomerular nephritis is an entity caused by infection of the cardiac valves. IRGN is most common in children, and post-streptococcal glomerulonephritis (PSGN) is commonest in the age group of 2-14 years.

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Direct conversion of naphthoxazines to diverse xanthene derivatives was achieved under one-pot operation through deconstructive annulation methodology. Sequential oxidative C(sp)-O/C(sp)-N cleavage followed by intramolecular/intermolecular annulation reaction was carried out under aerobic reaction conditions. Mechanistic analyses performed on the substrate revealed that the C(sp)-O bond cleavage supersedes the C(sp)-N bond scission.

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