Publications by authors named "B Malachowska"
There are available studies assessing the development of maxillary sinuses in relation to the viscerocranium. However, there are no publications analyzing the development of maxillary sinuses in relation to the development of the cranium, i.e.
View Article and Find Full Text PDFWhole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality.
Int J Radiat Oncol Biol Phys
September 2024
Article Synopsis
- - The study investigates the effects of ultrahigh dose-rate FLASH proton therapy on gastrointestinal injury, highlighting that while FLASH therapy aims to reduce normal tissue toxicity, it showed significantly reduced survival rates in mice compared to conventional therapy.
- - Whole abdominal irradiation was conducted on mice, using both FLASH and conventional proton therapy, and survival rates were assessed, along with intestinal histology analysis through a new AI-based technique.
- - Results indicated that despite enhanced dose rates with FLASH therapy, there was no significant improvement in gut cell regeneration or histology at 4 days post-irradiation, raising questions about FLASH's efficacy for gastrointestinal sparing.
Treating radioresistant and bulky tumors is challenging due to their inherent resistance to standard therapies and their large size. GRID and lattice spatially fractionated radiation therapy (simply referred to GRID RT and LRT) offer promising techniques to tackle these issues. Both approaches deliver radiation in a grid-like or lattice pattern, creating high-dose peaks surrounded by low-dose valleys.
View Article and Find Full Text PDFBackground: Acute radiation syndrome (ARS) manifests after exposure to high doses of radiation in the instances of radiologic accidents or incidents. Facilitating regeneration of the bone marrow (BM), namely the hematopoietic stem and progenitor cells (HSPCs), is key in mitigating ARS and multi-organ failure. JNJ-26366821, a PEGylated thrombopoietin mimetic (TPOm) peptide, has been shown as an effective medical countermeasure (MCM) to treat hematopoietic-ARS (H-ARS) in mice.
View Article and Find Full Text PDFBackground: Racial disparities in oncological outcomes resulting from differences in social determinants of health (SDOH) and tumour biology are well described in prostate cancer (PCa) but similar inequities exist in bladder (BCa) and renal cancers (RCCs). Precision medicine (PM) aims to provide personalized treatment based on individual patient characteristics and has the potential to reduce these inequities in GU cancers.
Objective: This article aims to review the current evidence outlining racial disparities in GU cancers and explore studies demonstrating improved oncological outcomes when PM is applied to racially diverse patient populations.