Exploring Self-Supervised Models for Depressive Disorder Detection: A Study on Speech Corpora.

Automatic detection of depressive disorder from speech signals can help improve medical diagnosis reliability. However, a significant challenge in this field is that most of the available depression datasets are relatively small, which limits the effectiveness of sophisticated deep-learning approaches. In this work, we study low-resource, speech-based depression corpora to explore the effect of speech embeddings for depression detection.

Effect of π-Linkages in Covalent Organic Framework-Catalyzed Light-Harvesting Thioesterification Reaction.

Covalent organic frameworks (COFs) serve as an outstanding platform for heterogeneous photocatalysis. We synthesized two analogous pyrene-based two-dimensional COFs with π-conjugated networks, one linked by C═N bonds and the other by C═C bonds, through Schiff base and Knoevenagel condensation reactions, respectively. We investigated the impact of these linkages on the photocatalytic activity of these COFs, using visible-light-mediated thioesterification as a model reaction.

Phosphine-Based Porous Organic Polymer-Stabilized Palladium Nanoparticle Catalyst for the Regioselective Synthesis of Indenones.

Phosphorus-embedded porous organic polymers (P-POPs) play a vital role in catalysis and sustainable chemical synthesis. This study uses an olefin-linked P-POP to stabilize Pd nanoparticles that catalyze Larock's annulation to synthesize symmetrical indenones in high yields. Unsymmetric indenones were obtained with exclusive regioselectivities by employing an intramolecular dicarbofunctionalization of a modular alkyne.

Design, synthesis and biological evaluation of new class of pyrazoles-dihydropyrimidinone derivatives as bone anabolic agents.

This study explores a series of twenty-four newly synthesized pyrzole-dihydropyrimidinone hybrids as potential bone anabolic agents. Initially, an alkaline phosphatase assay, a common marker of bone formation, was used to screen all compounds for their ability to stimulate osteogenic potential. Initial screening identified three promising candidates (5f, 5u and 5w) that were subsequently confirmed to be non-toxic to osteoblasts.

Cobalt-Catalyzed Enantioselective Reductive Coupling of Imines and Internal Alkynes.

Chiral allylamines are important structural components in natural products, pharmaceuticals, and chiral catalysts. Herein, we report a cobalt-catalyzed enantioselective reductive coupling of imines with internal alkynes to synthesize chiral allylamines. The reaction is catalyzed by a cobalt complex derived from commercially available bisphosphine ligand utilizing zinc as the electron donor.