Electrical behaviour of the rat's tibia during growth and fracture healing.

The electrical behaviour of the exposed tibial surface of young rats has been studied in normal conditions, after fracture and during the repair process. Recordings of potentials were made after all the electrical artefacts (muscle injury potentials) had been neutralized. No significant potential difference was obtained on the exposed bony surface in all the specimens.

Experimental model for studying the invasive characteristics of malignant tumours transplanted in bone and muscle of rats.

The subject of experimental research in bone oncology is comparatively neglected in the literature though it is recognised that such research could offer fundamental contributions to our knowledge of the biological behaviour of tumours in bone. A model for experimental study is proposed which is easy to carry out and effective in producing results. It consists of transplanting a highly malignant tumour with a 100 per cent "take" rate, such as Guérin's T8 or Oberling's aleukemic myeloma, in the tibia or femur of the rat.