Our path together: Development of the inclusive parenting goals questionnaire.

Instruments on parenting goals are often outdated and don't consider goals related to capabilities and needs of children with (severe) disabilities. This study aimed to develop an inclusive questionnaire on parenting goals applicable to parents of all children (0-21 years). The iterative development process relied on academic and experiential expertise of parents and professionals; and included consultation of relevant literature, interviews with 6 parents of a child with severe to profound intellectual disabilities, a feedback round with diverse stakeholders, and a pilot study.

Long-Term Results from an Open-Label Extension Study of Atacicept for the Treatment of IgA Nephropathy.

Background: B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL) play key roles in the pathogenesis of IgA nephropathy. Atacicept is a novel fully humanized fusion protein, self-administered at home by subcutaneous injection, that binds and inhibits BAFF and APRIL. By inhibiting BAFF and APRIL, atacicept targets the underlying B-cell–mediated pathogenesis driving disease progression.

Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy.

Background: The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway.

Methods: In this phase 3, double-blind, randomized, placebo-controlled trial, we enrolled adults with biopsy-confirmed IgA nephropathy and proteinuria (defined as a 24-hour urinary protein-to-creatinine ratio of ≥1 [with protein and creatinine both measured in grams]) despite optimized supportive therapy.

Concurrent photothermal therapy and nuclear magnetic resonance imaging with plasmonic-magnetic nanoparticles: A numerical study.

Background And Objective: Theranostics is the combination of the diagnostic and therapeutic phases. Here we focus on simultaneous use of photothermal therapy and magnetic resonance imaging, employing a contrast-photothermal agent that converts incident light into heat and affects the transverse relaxation time, a key magnetic resonance imaging parameter. Our work considers a gold-magnetite nanoshell platform to gauge the feasibility of magnetic resonance imaging monitoring of the heating associated with phototherapy, by studying the modification of the transverse relaxation rate induced by laser illumination of a solution containing these hybrid nanoparticles.