Burr Hole Hemispherotomy: Case Series.

Background And Objectives: Hemispherotomy represents definitive treatment for drug-resistant epilepsy with unilateral hemispheric onset. Traditional approaches involve a large incision and open craniotomy, with associated risks of blood loss, infection, poor wound healing, pain, cosmetic concerns, and long hospital stays. The authors describe a minimally invasive hemispherotomy technique through a single burr hole overlying the Sylvian fissure.

Establishing carbapenem resistant organism surveillance, prevention, and control in a middle-income country: implementation of a hospital-based program in Fiji.

Antimicrobial resistance (AMR) is a major public health threat with the highest burden being estimated to be in low- and middle-income countries. Fiji is an upper-middle-income country in Oceania. Recent studies from Fiji highlighted the increasing burden of carbapenem resistant organisms (CRO) such as Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli.

Intentions for the prevention of hepatitis B and C among healthcare workers in a tertiary facility in Ghana.

Objectives: Hepatitis B and C virus (HBV and HCV, respectively) infections pose a significant occupational hazard to healthcare workers (HCWs) globally, with increased risk due to exposure to blood and body fluids. In Sub-Saharan Africa, including Ghana, the prevalence of these infections among HCWs remains high, despite existing prevention measures. Understanding the factors influencing HCWs' preventive behaviors is crucial for developing effective interventions to reduce transmission risks in healthcare settings.

Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans.

Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features in humans remain poorly understood. Here we performed machine learning-augmented analysis of published single-cell RNA-sequencing datasets and identified macaque imGCs with transcriptome-wide immature neuronal characteristics. Our cross-species comparisons among humans, monkeys, pigs, and mice showed few shared (such as DPYSL5), but mostly species-specific gene expression in imGCs that converged onto common biological processes regulating neuronal development.