The impact of frailty Screening of Older adults with muLtidisciplinary assessment of those At Risk during emergency hospital attendance on the quality, safety and cost-effectiveness of care (SOLAR): a randomised controlled trial.

Background: Older people account for 25% of all Emergency Department (ED) admissions. This is expected to rise with an ageing demographic. Older people often present to the ED with complex medical needs in the setting of multiple comorbidities.

Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies.

Glioblastoma (GBM), a highly invasive and vascular malignancy is shown to rapidly develop resistance and evolve to a more invasive phenotype following bevacizumab (Bev) therapy. Rho Guanine Nucleotide Exchange Factor proteins (RhoGEFs) are mediators of key components in Bev resistance pathways, GBM and Bev-induced invasion. To identify GEFs with enhanced mRNA expression in the leading edge of GBM tumours, a cohort of GEFs was assessed using a clinical dataset.

Introduction to dynamics of manufacturing supply networks.

Manufacturing supply networks are complex dynamic networks that play a crucial role in the economy. Nevertheless, there are so far only few studies that apply modern tools of network science and dynamical system theory to the analysis of these networks. Here, we provide a brief introduction to these types of networks highlighting their basic organization, current challenges, and selected previous work.

Revealing instabilities in a generalized triadic supply network: A bifurcation analysis.

Supply networks are exposed to instabilities and thus a high level of risk. To mitigate this risk, it is necessary to understand how instabilities are formed in supply networks. In this paper, we focus on instabilities in inventory dynamics that develop due to the topology of the supply network.

A new model of scheduling in manufacturing: tasks, roles, and monitoring.

For over 3 decades there was a belief that computer-based solutions would "solve" complex industrial scheduling problems, yet most manufacturing organizations still require human contributions for effective scheduling performance. We present a new model of scheduling for the development and implementation of effective scheduling systems within manufacturing companies. The model derives from investigating the work of 7 schedulers in 4 manufacturing environments using a qualitative field study approach, for which novel field-based data collection and analysis methods were developed.