Acetylator phenotypes in diabetes mellitus.

The purpose of this study was to establish the correlation between the genetically determined rate of acetylation of certain drugs and the development of diabetic neuropathy. Acetylator phenotype was determined according to Evans in 100 healthy individuals and 160 diabetics including 80 patients with type I and 80 with type II diabetes. The diagnosis of diabetic neuropathy was based on clinical neurological examination.

[Electrophysiologic changes in peripheral nerves in patients with 2 acetylation types of diabetes mellitus].

The purpose of the work was checking whether possible electrophysiological changes in peripheral nerves in diabetes were connected with acetylation phenotype. The authors determined the conduction velocity in peripheral nerves (medianus, peroneal, femoral, facial and sural) in 49 diabetics, divided into two groups depending on the acetylation phenotype determined by Evans method. The results failed to demonstrate differences in the frequency of neuropathy between both groups of acetylators.

Serum C peptide and IRI levels after administration of glucagon and glucose in non-insulin-dependent diabetics.

A comparative study was carried out on B cell response to alternative intravenous glucagon (1.0 mg) and intravenous glucose (0.33 g per kg body weight) in healthy non-obese persons (c-NOb), healthy obese persons (C-Ob), non-obese non-insulin-dependent diabetics (NIDD-NOb) and obese non-insulin-dependent diabetics (NIDD-Ob).