Publications by authors named "B M-W Illigens"
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms like bradykinesia, tremor, rigidity, and postural instability. Additionally, PD severely impacts physical abilities and independence. Chronic pain, affecting 67.
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- - Atrioventricular block (AVB) is uncommon in hyperthyroidism, and this study aimed to clarify its prevalence, types, management, and outcomes through a systematic review of existing literature.
- - The review included 56 studies with 87 patients, revealing that complete heart block (CHB) was the most frequent form of AVB, affecting over 51% of those studied, and only a small number required pacemaker insertion.
- - Findings indicate that while CHB is prevalent, most cases in hyperthyroid patients can be treated effectively with anti-thyroid medications, with limited differences in outcomes based on whether patients received pacing.
Background And Purpose: We characterized autonomic pilomotor and sudomotor skin function in early Parkinson's disease (PD) longitudinally.
Methods: We enrolled PD patients (Hoehn and Yahr 1-2) and healthy controls from movement disorder centers in Germany, Hungary, and the United States. We evaluated axon-reflex responses in adrenergic sympathetic pilomotor nerves and in cholinergic sudomotor nerves and assessed sympathetic skin response (SSR), predominantly parasympathetic neurocardiac function via heart rate variability, and disease-related symptoms at baseline, after 2 weeks, and after 1 and 2 years.
Purpose: Immune imbalances in major depressive disorder (MDD) have been targeted by anti-inflammatory treatment approaches in clinical trials to increase responsiveness to therapy. However, even after several meta-analyses, no translation of evidence into clinical practice has taken place. We performed a systematic review to evaluate meta-analytic evidence of randomized controlled trials on the use of anti-inflammatory agents for MDD to summarize efficacy estimates and elucidate shortcomings.
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